Improving access to essential medicines to reduce postpartum hemorrhage morbidity and mortality. Guest Editors: Charles Ameh and Fernando Althabe. IJGO Supplement Editors: Homa Ahmadzia and Lisa Rahangdale. This supplement was supported by funding from MSD, through its MSD for Mothers initiative and is the sole responsibility of the authors. MSD for Mothers is an initiative of Merck & Co., Inc., Rahway, NJ, USA

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1-3
  • First Published: 28 June 2022

EDITORIAL

Open Access

Improving postpartum hemorrhage care: Policy, practice, and research

  • Pages: 4-5
  • First Published: 28 June 2022
Synopsis

Reducing the risk of death from PPH requires evidence-based care, innovations, and addressing demand and supply-side bottlenecks around quality, availability, and use of uterotonics.

COMMENTARY

Open Access

FIGO and the International Confederation of Midwives endorse WHO guidelines on prevention and treatment of postpartum hemorrhage

  • Pages: 6-10
  • First Published: 28 June 2022
Synopsis

FIGO and the International Confederation of Midwives produced two joint statements endorsing WHO guidelines on prevention and treatment of postpartum hemorrhage.

SUPPLEMENT ARTICLES

Open Access

Challenges in updating national guidelines and essential medicines lists in Sub-Saharan African countries to include WHO-recommended postpartum hemorrhage medicines

  • Pages: 11-13
  • First Published: 28 June 2022
Synopsis

Challenges in achieving timely national policy updates to address prevention and treatment of postpartum hemorrhage (PPH) are highlighted, with the goal of reducing maternal morbidity and mortality in countries with a high burden of PPH.

Open Access

A synthesis of clinical and health system bottlenecks to implementing new WHO postpartum hemorrhage recommendations: Secondary data analysis of the Kenya Confidential Enquiry into Maternal Deaths 2014–2017

  • Pages: 14-22
  • First Published: 28 June 2022
Synopsis

Improving quality of care for women with postpartum hemorrhage requires use of up-to-date clinical guidelines combined with focused health system interventions.

Open Access

Differences in obstetric practices and outcomes of postpartum hemorrhage across Nigerian health facilities

  • Pages: 23-30
  • First Published: 28 June 2022
Synopsis

There is large, unexplained variability in obstetric practices, rates of postpartum hemorrhage, laparotomies, and deaths due to postpartum hemorrhage across Nigerian facilities.

Open Access

Innovations in the prevention and treatment of postpartum hemorrhage: Analysis of a novel medicines development pipeline database

  • Pages: 31-39
  • First Published: 28 June 2022
Synopsis

A new database of maternal medicine development shows few new PPH candidates are in the pipeline. Significant investment is needed, particularly in early-phase research.

Open Access

Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review

  • Pages: 40-45
  • First Published: 28 June 2022
Synopsis

Intravenous tranexamic acid (TXA) reduces death due to bleeding if given as soon as possible after birth and no later than 3 hours. TXA orally takes about 1 hour to reach minimum therapeutic concentration in postpartum women. Intramuscular TXA achieves therapeutic concentration within 5 minutes in healthy volunteers and in shocked trauma patients.