Volume 47, Issue 9 p. 3008-3033
Report

Clinical guidance for peripartum management of patients with hereditary thrombophilia

Takao Kobayashi

Corresponding Author

Takao Kobayashi

Department of Obstetrics and Gynecology, Hamamatsu Medical Center, Hamamatsu, Japan

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Correspondence: Takao Kobayashi, Hamamatsu Medical Center, 328 Tomitsuka-cho, Naka-ku, Hamamatsu 432-8580, Japan.

Email: [email protected]

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Eriko Morishita

Eriko Morishita

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Department of Laboratory Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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Hiroko Tsuda

Hiroko Tsuda

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Institute of Distribution Sciences, Nakamura Gakuen University, Fukuoka, Japan

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Reiko Neki

Reiko Neki

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Division of Counseling for Medical Genetics, Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Suita, Japan

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Tetsuhito Kojima

Tetsuhito Kojima

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Medical Division, Aichi Health Promotion Foundation, Nagoya, Japan

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Shouichi Ohga

Shouichi Ohga

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Masayuki Ochiai

Masayuki Ochiai

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Tomoko Adachi

Tomoko Adachi

Department of Obstetrics and Gynecology, Aiiku Maternal and Child Health Center, Aiiku Hospital, Tokyo, Japan

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Toshiyuki Miyata

Toshiyuki Miyata

The Study Group for Hereditary Thrombophilia, Research on Blood Coagulation Abnormalities, Research Program on Rare and Intractable Diseases, The Ministry of Health, Labour and Welfare Science Research Grants, Tokyo, Japan

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan

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First published: 24 June 2021
Citations: 3

Abstract

Hereditary thrombophilia is a condition in which individuals are susceptible to the formation of thrombi due to a hereditary deficiency in anticoagulant factors, antithrombin (AT), protein C (PC), or protein S (PS). Many Japanese thrombophilia patients have PS deficiency, especially PS p.K196E (also called as PS Tokushima), which is exclusive to the Japanese population, and thrombosis sometimes occurs during pregnancy. At present, no management guidelines for pregnancy and delivery in thrombophilia patients have been developed. The Study Group for Hereditary Thrombophilia, one of the research groups of blood coagulation abnormalities in the Research Program on Rare and Intractable Diseases supported with the Research Grants of the Ministry of Health, Labour and Welfare Science, has therefore developed this clinical guidance to provide healthcare workers with necessary information on safe pregnancy, parturition and neonatal management, adopting a format of responses to seven clinical questions (CQ). At the end of each answer, the corresponding Recommendation Level (A, B, C) is indicated.

Conflict of Interest

No declaration.

Data Availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.