Volume 110, Issue 11 p. 1029-1031

Microvascular dysfunction: a link between pre-eclampsia and maternal coronary heart disease

Jane E. Ramsay

Corresponding Author

Jane E. Ramsay

*Dr J. Ramsay, University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, 3rd Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK.Search for more papers by this author
Frances Stewart

Frances Stewart

Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK

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Ian A. Greer

Ian A. Greer

Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK

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Naveed Sattar

Naveed Sattar

Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, UK

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First published: 22 December 2003
Citations: 105

Abstract

Epidemiological studies have recently demonstrated a relationship between pre-eclampsia and coronary heart disease. Insulin resistance has been implicated as a common factor. We have demonstrated, for the first time, using laser Doppler imaging in vivo, impaired microvascular function in women 15–25 years following a pregnancy complicated by pre-eclampsia. Thus, microvascular dysfunction, which is associated with insulin resistance, may be a predisposing vascular mechanism for both coronary heart disease and pre-eclampsia. Pregnancies complicated by pre-eclampsia may identify women at risk of vascular disease in later life and may provide the opportunity for lifestyle and risk factor modification to alter maternal vascular disease risk.