Volume 94, Issue 5 p. 454-460

Microbiological and histopathological findings in acute pelvic inflammatory disease

J. PAAVONEN

Corresponding Author

J. PAAVONEN

Departments of Clinical and Biomedical Sciences, University of Tampere

J. Paavonen, MD, Department of Obstetrics and Gynecology, University Central Hospital, SF-00290 Helsinki, FinlandSearch for more papers by this author
K. TEISALA

K. TEISALA

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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P. K. HEINONEN

P. K. HEINONEN

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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R. AINE

R. AINE

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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S. LAINE

S. LAINE

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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M. LEHTINEN

M. LEHTINEN

Departments of Clinical and Biomedical Sciences, University of Tampere

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A. MIETTINEN

A. MIETTINEN

Departments of Clinical and Biomedical Sciences, University of Tampere

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R. PUNNONEN

R. PUNNONEN

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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P. GRÖNROOS

P. GRÖNROOS

Departments of Obstetrics and Gynecology, Medical Microbiology and Pathology, University Central Hospital, Tampere, Finland

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First published: May 1987
Citations: 124

Summary

Upper genital tract infection was investigated in 45 women admitted to hospital for suspected acute pelvic inflammatory disease (PID). Salpingitis was diagnosed by laparoscopy in 30 (67%) women. Histopathological evidence of endometritis was found significantly more often in the 30 women with salpingitis (87%) than in the other 15 women without salpingitis (33%). C. trachomatis or N. gonorrhoeas, or both, were isolated from the upper genital tract in 14 of the 31 women who had both salpingitis and endometritis or endometritis only but in none of the four women who had salpingitis alone and in none of the 10 women who had no evidence of PID. Bacterial vaginosis was associated with histopathological evidence of upper tract infection. Non-chlamydial nongonococcal organisms were frequently isolated from the upper genital tract. No organisms were isolated from the upper genital tract from 9 of 35 women with laparoscopic or histopathological evidence of PID compared with 7 of 10 women without evidence of PID. C, trachomatis or N. gonorrhoeae in the endometrium was associated with lymphoid follicles comprising transformed lymphocytes, and correlated with the density of plasma cells on biopsy. The microbiological results support the recommendations of broad spectrum antimicrobial therapy for PID.