BJOG: An International Journal of Obstetrics & Gynaecology

Systematic Review

Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis

Corresponding Author

N Mitchell-Jones

[email protected]

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

Correspondence: N Mitchell-Jones, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK. Email [email protected]Search for more papers by this author

I Gallos,

I Gallos

University of Birmingham, Birmingham, UK

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J Farren,

J Farren

St Mary's Hospital, London, UK

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A Tobias,

A Tobias

University of Birmingham, Birmingham, UK

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C Bottomley,

C Bottomley

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

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T Bourne,

T Bourne

Tommy's National Centre for Miscarriage Research, Queen Charlottes and Chelsea Hospital, Imperial College, London, UK

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N Mitchell-Jones,

Corresponding Author

N Mitchell-Jones

[email protected]

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

Correspondence: N Mitchell-Jones, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK. Email [email protected]Search for more papers by this author

I Gallos,

I Gallos

University of Birmingham, Birmingham, UK

Search for more papers by this author

J Farren,

J Farren

St Mary's Hospital, London, UK

Search for more papers by this author

A Tobias,

A Tobias

University of Birmingham, Birmingham, UK

Search for more papers by this author

C Bottomley,

C Bottomley

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

Search for more papers by this author

T Bourne,

T Bourne

Tommy's National Centre for Miscarriage Research, Queen Charlottes and Chelsea Hospital, Imperial College, London, UK

Search for more papers by this author

First published: 14 July 2016

https://doi.org/10.1111/1471-0528.14180

Citations: 84

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Abstract

Background

Psychological illness occurring in association with hyperemesis gravidarum (HG) has been widely reported.

Objective

To determine if there is a higher incidence of psychological morbidity in women with HG compared with women without significant nausea and vomiting in pregnancy.

Search strategy

PubMed, MEDLINE, Embase and PsychINFO were searched up to September 2015.

Selection criteria

Articles referring to psychological morbidity in relation to HG. For meta-analysis case–control studies using numerical scales to compare psychological symptoms.

Data collection and analysis

Articles were independently assessed for inclusion by two reviewers and methodology was appraised using the Newcastle Ottawa Scale. Comparison was made using the standard mean difference (SMD) in symptom scale scores.

Main results

In all, 59 articles were included in the systematic review, 12 of these were used in the meta-analysis. Meta-analysis of depression scale scores demonstrated a very large effect with statistically significantly higher depression scale scores in women with HG (SMD 1.22; 95% CI 0.80–1.64; P ≤ 0.01) compared with controls. Meta-analysis of anxiety scores demonstrated a large effect with statistically significantly higher anxiety disorder scale scores in women with HG (SMD 0.86; 95% CI 0.53–1.19; P ≤ 0.01). In both analyses significant heterogeneity was identified (depression and HG I² = 94%, P ≤ 0.01; anxiety and HG I² = 84%, P = 0.02).

Conclusions

Our systematic review and meta-analysis have shown a significantly increased frequency of depression and anxiety in women with HG. The findings should prompt service development for women with HG that includes provision of psychological care and support.

Tweetable abstract

Meta-analysis demonstrates an increase in #PsychologicalMorbidity in women with #HyperemesisGravidarum

Supporting Information

References

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Citing Literature

Volume124, Issue1

January 2017

Pages 20-30

This article also appears in:

Women's Mental Health

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bjo14180-sup-0001-AppendixS1.pdfPDF document, 80.4 KB	Appendix S1. Tabulation of all articles reviewed but not included in meta-analysis.
bjo14180-sup-0002-2015-SR-17044-s02.pdfPDF document, 1.2 MB
bjo14180-sup-0003-2015-SR-17044-s03.pdfPDF document, 1.2 MB
bjo14180-sup-0004-2015-SR-17044-s04.pdfPDF document, 1.2 MB
bjo14180-sup-0005-2015-SR-17044-s05.pdfPDF document, 1.2 MB
bjo14180-sup-0006-2015-SR-17044-s06.pdfPDF document, 1.2 MB
bjo14180-sup-0007-2015-SR-17044-s07.pdfPDF document, 1.2 MB

Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis

Abstract

Background

Objective

Search strategy

Selection criteria

Data collection and analysis

Main results

Conclusions

Tweetable abstract

Supporting Information

References

Citing Literature

References

Information

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Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis

Abstract

Background

Objective

Search strategy

Selection criteria

Data collection and analysis

Main results

Conclusions

Tweetable abstract

Supporting Information

References

Citing Literature

References

Related

Information