Future risk of diabetes in mother and child after gestational diabetes mellitus

Corresponding Author

Peter Damm

[email protected]

Center for Pregnant Women with Diabetes, Department of Obstetrics and Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Center for Pregnant Women with Diabetes, Department of Obstetrics 4031, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Tel.: +45 4054 1334.Search for more papers by this author

Peter Damm,

Corresponding Author

Peter Damm

[email protected]

Center for Pregnant Women with Diabetes, Department of Obstetrics and Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Center for Pregnant Women with Diabetes, Department of Obstetrics 4031, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Tel.: +45 4054 1334.Search for more papers by this author

First published: 02 December 2016

https://doi.org/10.1016/j.ijgo.2008.11.025

Citations: 159

Share a link

Email
Facebook
x
LinkedIn
Reddit
Wechat

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy complication with increased maternal and perinatal morbidity. However, significant long-term morbidity also exists for the mother and offspring. Women with previous GDM have a very high risk of developing overt diabetes, primarily type 2 diabetes, later in life. Moreover, the risk of the metabolic syndrome is increased 3-fold in these women. Their offspring have an 8-fold risk of diabetes/prediabetes at 19–27 years of age. Thus, GDM is part of a vicious circle which increases the development of diabetes in the coming generations.

References

[1]King, H.. Epidemiology of glucose intolerance and gestational diabetes in women of childbearing age. Diabetes Care. 21(Suppl 2): 1998; B9–B13
PubMedWeb of Science®Google Scholar
[2]Crowther, C.A., Hiller, J.E., Moss, J.R., McPhee, A.J., Jeffries, W.S., Robinson, J.S.. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 352(24): 2005; 2477–2486
10.1056/NEJMoa042973
CASPubMedWeb of Science®Google Scholar
[3]O'Sullivan, J.B.. The Boston Gestational Diabetes Studies: Review and Perspectives. H.W. Sutherland, J.M. Stowers Carbohydrate Metabolism in Pregnancy and the Newborn IV. 1989; Springer-Verlag: Berlin; 287–294
10.1007/978-1-4471-1680-6_26
Google Scholar
[4]Lauenborg, J., Mathiesen, E.R., Mølsted-Pedersen, L., Damm, P.. Diabetes mellitus and the metabolic syndrome after gestational diabetes (GDM). M. Hod, L.G. Jovanovic, G.C. Di Renzo Textbook of Diabetes and Pregnancy. 2nd ed.. 2008; Informa Healthcare: London; 379–385
10.3109/9781439802007.050
Google Scholar
[5]Kim, C., Newton, K.M., Knopp, R.H.. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care. 25(10): 2002; 1862–1868
10.2337/diacare.25.10.1862
PubMedWeb of Science®Google Scholar
[6]Damm, P., Kühl, C., Bertelsen, A., Mølsted-Pedersen, L.. Predictive factors for development of diabetes in women with previous gestational diabetes. Am J Obstet Gynecol. 167(3): 1992; 607–616
10.1016/S0002-9378(11)91559-2
PubMedWeb of Science®Google Scholar
[7]Lauenborg, J., Hansen, T., Jensen, D.M., Vestergaard, H., Mølsted-Pedersen, L., Hornnes, P., et al.Increasing incidence of diabetes after gestational diabetes mellitus: a long-term follow-up in a Danish population. Diabetes Care. 27(5): 2004; 1194–1199
10.2337/diacare.27.5.1194
PubMedWeb of Science®Google Scholar
[8]Bendixen, H., Holst, C., Sørensen, T.I., Raben, A., Bartels, E.M., Astrup, A.. Major increase in prevalence of overweight and obesity between 1987 and 2001 among Danish adults. Obes Res. 12(9): 2004; 1464–1472
10.1038/oby.2004.183
PubMedWeb of Science®Google Scholar
[9]Verrma, A., Boney, C.M., Tucker, R., Vohr, B.R.. Insulin resistance syndrome in women with prior history of gestational diabetes mellitus. J Clin Endocrinol Metab. 87(7): 2002; 3227–3235
PubMedWeb of Science®Google Scholar
[10]Lauenborg, L., Mathiesen, E., Hansen, T., Glümer, C., Jørgensen, T., Borch-Johnsen, K., et al.The prevalence of the metabolic syndrome in a Danish population of women with previous GDM is 3-fold higher than in the general population. J Clin Endocrinol Metab. 90(7): 2005; 4004–4010
10.1210/jc.2004-1713
CASPubMedWeb of Science®Google Scholar
[11]Cheung, N.W., Byth, K.. Population health significance of gestational diabetes. Diabetes Care. 26(7): 2003; 2005–2009
10.2337/diacare.26.7.2005
PubMedWeb of Science®Google Scholar
[12]Tuomilehto, J., Lindstrom, J., Eriksson, J.G., Valle, T.T., Hamalainen, H., Ilanne-Parikka, P., et al.Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 344(18): 2001; 1343–1350
10.1056/NEJM200105033441801
CASPubMedWeb of Science®Google Scholar
[13]Knowler, W.C., Barrett-Connor, E., Fowler, S.E., Hamman, R.F., Lachin, J.M., Walker, E.A., et al.Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 346(6): 2002; 393–403
CASPubMedWeb of Science®Google Scholar
[14]Buchanan, T.A., Xiang, A.H., Peters, R.K., Kjos, S.L., Marroquin, A., Goico, J., et al.Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes. 51(9): 2002; 2796–2803
10.2337/diabetes.51.9.2796
CASPubMedWeb of Science®Google Scholar
[15]Stage, E., Ronneby, H., Damm, P.. Lifestyle change after gestational diabetes. Diab Res Clin Pract. 63(1): 2004; 67–72
10.1016/j.diabres.2003.08.009
PubMedWeb of Science®Google Scholar
[16]Aerts, L., Van Assche, F.A.. Animal evidence for the transgenerational development of diabetes mellitus. Int J Biochem Cell Biol. 38(5–6): 2006; 894–903
10.1016/j.biocel.2005.07.006
CASPubMedWeb of Science®Google Scholar
[17]Pettitt, D.J., Bennett, P.H., Saad, M.F., Charles, M.A., Nelson, R.G., Knowler, W.C.. Abnormal glucose tolerance during pregnancy in Pima Indian women. Long-term effects on offspring. Diabetes. 40(Suppl 2): 1991; 126–130
10.2337/diab.40.2.S126
PubMedWeb of Science®Google Scholar
[18]Dabelea, D.. The predisposition to obesity and diabetes in offspring of diabetic mothers. Diabetes Care. 30(Suppl 2): 2007; S169–S174
10.2337/dc07-s211
PubMedWeb of Science®Google Scholar
[19]Clausen, T.D., Mathiesen, E.R., Hansen, T., Pedersen, O., Jensen, D.M., Lauenborg, J., et al.High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia. Diabetes Care. 31(2): 2008; 340–346
10.2337/dc07-1596
PubMedWeb of Science®Google Scholar
[20]Seshiah, V., Balaji, V., Balaji, M.S., Paneerselvam, A., Arthi, T., Thamizharasi, M., et al.Prevalence of gestational diabetes mellitus in South India (Tamil Nadu)–a community based study. J Assoc Phys India. 56: 2008; 329–333
CASPubMedGoogle Scholar

Citing Literature

Volume104, IssueSupplement

Diabetes, Women and Development: Report and Papers from an Expert Meeting

March 2009

Pages S25-S26

Future risk of diabetes in mother and child after gestational diabetes mellitus

Abstract

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Future risk of diabetes in mother and child after gestational diabetes mellitus

Abstract

References

Citing Literature

References

Related

Information