Improved diagnosis in nonimmune hydrops fetalis using a standardized algorithm
Corresponding Author
Marie Laterre
Centre for Human Genetics, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Obstetrics Department, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Correspondence
Marie Laterre, Centre de Génétique Humaine—CGH, Cliniques universitaires St. Luc, UCL, 1200 Brussels, Belgium.
Email: [email protected]
Search for more papers by this authorPierre Bernard
Obstetrics Department, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Search for more papers by this authorMiika Vikkula
Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Center for Vascular Anomalies, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Walloon Excellence in Life Sciences and Biotechnology (WELBIO), de Duve Institute, UCL., Brussels, Belgium
Search for more papers by this authorYves Sznajer
Centre for Human Genetics, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Search for more papers by this authorCorresponding Author
Marie Laterre
Centre for Human Genetics, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Obstetrics Department, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Correspondence
Marie Laterre, Centre de Génétique Humaine—CGH, Cliniques universitaires St. Luc, UCL, 1200 Brussels, Belgium.
Email: [email protected]
Search for more papers by this authorPierre Bernard
Obstetrics Department, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Search for more papers by this authorMiika Vikkula
Laboratory of Human Molecular Genetics, Christian de Duve Institute of Cellular Pathology, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Center for Vascular Anomalies, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Walloon Excellence in Life Sciences and Biotechnology (WELBIO), de Duve Institute, UCL., Brussels, Belgium
Search for more papers by this authorYves Sznajer
Centre for Human Genetics, Cliniques Universitaires St. Luc, UCL, Brussels, Belgium
Search for more papers by this authorAbstract
Objective
The aim of this study was to outline the disease etiology in a cohort of fetuses prenatally diagnosed with nonimmune hydrops fetalis (NIHF).
Methods
Based on a literature review, we defined precise criteria to select the NIHF cases. Those were further classified into 14 categories. To complete this first step, a literature review was performed by using homogeneous criteria to compare our results.
Results
Over the 10-year period, 102 fetuses were diagnosed with NIHF and included in the analysis. The etiology was identified in 86.3% (88/102) of them, with diagnostic distribution from the most prevalent to the least frequent (number of fetuses; %) being: chromosomal (33/102; 32.4%), lymphatic dysplasia (14; 13.7%), cardiovascular (10; 9.8%), “syndromic” (10; 9.8%), infection (8; 7.8%), and hematologic (8; 7.8%).
Conclusion
This literature review enabled us to emphasize the absence of homogeneous criteria used to define NIHF. When compared with literature, our data analysis highlighted the relevance of applying our full diagnostic approach to decrease the rate of idiopathic NIHF cases.
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