Volume 150, Issue 1 p. 47-52
Review Article

A systematic scoping review of COVID-19 during pregnancy and childbirth

Farida Elshafeey

Farida Elshafeey

Faculty of Medicine, Ain Shams University, Cairo, Egypt

These authors contributed equally.Search for more papers by this author
Rana Magdi

Rana Magdi

Faculty of Medicine, Ain Shams University, Cairo, Egypt

These authors contributed equally.Search for more papers by this author
Nader Hindi

Nader Hindi

Faculty of Medicine, Ain Shams University, Cairo, Egypt

These authors contributed equally.Search for more papers by this author
Mohamed Elshebiny

Mohamed Elshebiny

Faculty of Medicine, Ain Shams University, Cairo, Egypt

These authors contributed equally.Search for more papers by this author
Nourhan Farrag

Nourhan Farrag

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Shahd Mahdy

Shahd Mahdy

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Mohamed Sabbour

Mohamed Sabbour

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Sara Gebril

Sara Gebril

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Mohamed Nasser

Mohamed Nasser

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Menna Kamel

Menna Kamel

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Abdelrahman Amir

Abdelrahman Amir

Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Moataz Maher Emara

Moataz Maher Emara

Department of Anesthesia and Intensive care, Faculty of Medicine, Mansoura University, Mansoura, Egypt

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Ashraf Nabhan

Corresponding Author

Ashraf Nabhan

Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Egyptian Center for Evidence Based Medicine, Cairo, Egypt

Correspondence

Ashraf Nabhan, Faculty of Medicine, Ain Shams University, Abbassia Square, Cairo, Egypt.

Email: [email protected]

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First published: 24 April 2020
Citations: 229

Abstract

Background

Clinical presentation and outcomes of COVID-19 infection during pregnancy remain limited and fragmented.

Objectives

To summarize the existing literature on COVID-19 infection during pregnancy and childbirth, particularly concerning clinical presentation and outcomes.

Search strategy

A systematic search of LitCovid, EBSCO MEDLINE, CENTRAL, CINAHL, Web of Science, and Scopus electronic databases. The references of relevant studies were also searched.

Selection criteria

Identified titles and abstracts were screened to select original reports and cross-checked for overlap of cases.

Data collection and analysis

A descriptive summary organized by aspects of clinical presentations (symptoms, imaging, and laboratory) and outcomes (maternal and perinatal).

Main results

We identified 33 studies reporting 385 pregnant women with COVID-19 infection: 368 (95.6%) mild; 14 (3.6%) severe; and 3 (0.8%) critical. Seventeen women were admitted to intensive care, including six who were mechanically ventilated and one maternal mortality. A total of 252 women gave birth, comprising 175 (69.4%) cesarean and 77 (30.6%) vaginal births. Outcomes for 256 newborns included four RT-PCR positive neonates, two stillbirths, and one neonatal death.

Conclusion

COVID-19 infection during pregnancy probably has a clinical presentation and severity resembling that in non-pregnant adults. It is probably not associated with poor maternal or perinatal outcomes.

CONFLICTS OF INTEREST

The authors have no conflicts of interest.