Author Guidelines

Ethical Policy and Guidelines

Please click here to read the Ethical Policies of Prenatal Diagnosis.


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For additional tools visit Author Services, an enhanced suite of online tools for Wiley Online Library journal authors, featuring Article Tracking, E-mail Publication Alerts and Customized Research Tools.

To facilitate adherence to the author guidelines, it is recommended that authors use the Submission Checklist.


Prenatal Diagnosis is the Official Journal of the International Society for Prenatal Diagnosis (


Prenatal Diagnosis welcomes submissions in all aspects of prenatal screening and diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing:
  • prenatal cytogenetics, including microarrays
  • prenatal molecular genetics, including whole exome and whole genome sequencing
  • prenatal diagnosis of single gene disorders, including metabolic disorders
  • fetal transcriptome, proteome and metabolome studies
  • fetal cells and cell-free nucleic acids in maternal blood and other fluids
  • preimplantation genetic diagnosis and screening
  • fetal and placental development and pathology
  • fetal therapy
  • prenatal and preconceptional genetic screening
  • development and evaluation of laboratory services for prenatal testing
  • psychosocial, legal, ethical and economic aspects of prenatal testing
  • preconceptual, preimplantation and prenatal genetic counseling

The overriding criteria for publication are scientific merit, originality, and interest to a multidisciplinary audience.

The Journal may be viewed and all manuscripts should be submitted online at


Prenatal Diagnosis invites the following types of submission:

Original Articles

Original Articles are the Journal’s primary mode of scientific communication. Peer review of Original Articles will be handled by the most appropriate Editor . Original Articles must include a structured abstract (maximum 200 words), and should not exceed 3,500 words of body text. Original articles must also include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?

Review Articles

Review Articles will typically be solicited by the Review Editor. Authors who wish to submit an unsolicited review should first contact the Review Editor email: to determine its suitability for publication in the Journal. All reviews will be peer-reviewed. Review Articles must include an unstructured abstract (maximum 200 words), and should not exceed 3,500 words of body text, and are limited to 150 references. Review articles must also include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?

Research Letters

Case reports and clinical observations will be considered, but published as Research Letters. All Research Letters are peer-reviewed. Research Letters should not exceed 1,500 words, and are limited to 1 table, 1 figure, and 10 references. No abstract or key words are required, and text should be formatted in one continuous section. Research Letters must include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?

We work together with Wiley’s open access journals, Molecular Genetics and Genomic Medicine and Clinical Case Reports to enable rapid publication of good quality papers and case reports respectively, that we are unable to accept for publication in our journal. Authors rejected by our journal will be offered the option of having their paper or case report, along with any related peer reviews, automatically transferred for consideration by the Molecular Genetics and Genomic Medicine or Clinical Case Reports editorial team. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place.
Clinical Case Reports will consider case reports from every clinical discipline and may include clinical images or clinical videos. Clinical Case Reports is an open access journal, and article publication fees apply. For more information please go to
For more information on Molecular Genetics and Genomic Medicine please go to their website.


Correspondence (letters to the Editor) may be in response to issues arising from recently published articles, or short, free-standing pieces expressing an opinion. Letters are not subject to external peer-review.


All submissions should be made online at the Prenatal Diagnosis ScholarOne Manuscripts (formerly known as Manuscript Central) site— . New users should first create an account. Once a user is logged onto the site, submissions should be made via the Author Centre.

Supporting information should be submitted to ScholarOne Manuscripts as 'Supplementary materials for review'.


Manuscripts must be written in English.

Text should be supplied in a format compatible with Microsoft Word for Windows (PC). Charts and tables are considered textual and should also be supplied in a format compatible with Word. All figures (illustrations, diagrams, photographs) should be supplied in jpg, tiff or eps format.

All manuscripts must be typed in 12pt font and in double space with margins of at least 2.5 cm. Please insert continuous line numbers in the margin to assist reviewers (Microsoft Word > Page Layout > Line Numbers).

Original Articles and Reviews must comply with the word limits defined in section 2, and include:

Guidelines for Cover Submission

If you would like to send suggestions for artwork related to your manuscript to be considered to appear on the cover of the journal, please follow these general guidelines.

Covering Letters are encouraged, if you do include a covering letter please consider suggesting an Associate Editor to handle your submission.

Title Page

The first page of the manuscript should contain the following information:

1) the title of the paper
2) a running head not exceeding 70 characters (not required for Correspondence items)
3) manuscript word, table and figure count
4) names of authors as first name(s) followed by surnames
5) names of the institutions at which the research was conducted, clearly linked to respective authors
6) name, address, telephone number and email address of corresponding author
7) a statement of all funding sources that supported the work
8) any conflict of interest disclosures (see Section 5)
9) bulleted statements (maximum 70 words) in answer to each of the following questions: what's already known about this topic?; what does this study add? (not applicable to Correspondence items.)


Authors submitting Original Articles should note that structured abstracts (maximum 200 words) are required. The structured abstract should adopt the format: Objective, Method, Results, Conclusion. Abstracts should contain no citation to other published work.

Review Articles require abstracts (maximum 200 words) but they need not be structured.

Research Letters and Correspondence do not require abstracts.


This should in general, but not necessarily, be divided into sections with the headings: Introduction, Methods, Results, Discussion, Conclusion.

Research Letters and Correspondence should be formatted in one continuous section.

Tables and Figures

Tables and figures should not be inserted in the appropriate place in the text but should be included at the end of the paper, each on a separate page.

Tables and figures should be referred to in text as follows: Figure 1, Figure 2; Table 1, Table 2. The place at which a table or figure is to be inserted in the printed text should be indicated clearly on a manuscript. Each table and/or figure must have a legend that explains its purpose without reference to the text.

Any figure submitted as a colour original will appear in colour in the Journal's online edition free of charge. Colour figures will be printed in the Journal at no cost to the author if colour is necessary to the biomedical understanding (e.g., Doppler, FISH). Non-essential colour reproduction will only be considered on condition that authors contribute to the associated costs. Charges are: £300. (Colour charges will be waived for invited Review Articles.)

Authors are themselves responsible for obtaining permission to reproduce previously published figures or tables.


References should be in Vancouver format and appear as consecutive, unbracketed superscript numbers in the text, e.g. ‘in our previous reports1,2 and those of Smith et al. 3–5' and should be listed numerically in the reference list at the end of the article.

Format references as below, using standard (Medline) abbreviations for journal titles. If more than four authors, include the first three authors followed by et al.

1 Baraitser M. Uses of databases in dysmorphology. In Embryos, Genes and Birth Defects, Thorogood P (ed.). Chichester: John Wiley & Sons, 1997; 89–99.

2 Nolin SL, Glicksman A, Ding X, et al. Fragile X analysis of 1112 prenatal samples from 1991 to 2010. Prenat Diagn 2011; 31:925–31.

3 Petrikovsky BM. Fetal Disorders: Diagnosis and Management . New York: Wiley-Liss, 1998.

4 Smith A. Select committee report into social care in the community [WWW document]. URL [accessed on 7 November 2003].

Supporting Information

Prenatal Diagnosis is able to host online supporting information. Such material must be important ancillary information that is relevant to the parent article but which does not appear in the printed edition of the Journal. Supporting information will be published as submitted and will not be corrected or checked for scientific content, typographical errors or functionality.

Supporting information should be submitted to ScholarOne Manuscripts as 'Supplementary materials for review'.


Original Publication

Submission of a manuscript will be held to imply that it contains original unpublished work and is not being submitted for publication elsewhere at the same time. The author must supply a full statement to the Editor-in-Chief about all submissions and previous reports that might be regarded as redundant or duplicate publication of the same or very similar work.

Conflict of Interest

Authors are responsible for disclosing all financial and personal relationships between themselves and others that might bias their work. To prevent ambiguity, authors must state explicitly whether potential conflicts do or do not exist. Investigators should disclose potential conflicts to study participants and should state in the manuscript whether they have done so. Authors should describe the role of the study sponsor(s), if any, in study design, in the collection, analysis and interpretation of data, in the writing of the report and in the decision to submit the report for publication. If the supporting source had no such involvement, the authors should so state.


When reporting experiments on human subjects, indicate whether the procedures followed were approved by the ethical standards of the responsible committee on human experimentation (institutional or regional) and in accordance with the Helsinki Declaration. Do not use patients' names, initials or hospital numbers, especially in illustrative material. When reporting experiments on animals, indicate whether the institutions or a national research council's guide for, or any national law on, the care and use of laboratory animals was followed.

A statement describing explicitly the ethical background to the studies being reported must be included in all manuscripts in the Materials and Methods section. The full names of the Ethics committee/s or institutional review board/s that approved the study should be stated.

Images of, or information about, identifiable individuals

Patients have a right to privacy that should not be infringed without informed consent. It is the author’s responsibility to obtain consent from patients and other individuals for use of information, images, audio files, interview transcripts, and video clips from which they may be identified. To ensure we have the rights we require please provide a signed consent/release form in all instances.


- If the person is a minor, consent must be obtained from the child’s parents or guardians.
- If the person is dead, we consider it essential and ethical that you obtain consent for use from the next of kin. If this is impractical you need to balance the need to use the photo against the risk of causing offence. In all cases ensure you obscure the identity of the deceased.
- If using older material, or for material obtained in the field, for which signed release forms are, for practical purposes, unobtainable, you will need to confirm in writing that the material in question was obtained with the person’s understanding that it might be published.

Identifying details should be omitted if they are not essential but patient data should never be altered or falsified in an attempt to attain anonymity. Complete anonymity is difficult to achieve and informed consent should be obtained if there is any doubt. For example, masking the eye region in photographs of patients is inadequate protection of anonymity.

Ithenticate Plagiarism system:

The journal to which you are submitting your manuscript employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works.


All persons designated as authors should qualify for authorship and all those who qualify should be listed. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content. One or more authors should take responsibility for the integrity of the work as a whole, from inception to published article. Authorship credit should be based only on 1) substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; 2) drafting the article or revising it critically for important intellectual content; 3) final approval of the version to be published. Conditions 1, 2 and 3 must all be met. Acquisition of funding, the collection of data or general supervision of the research group, by themselves, do not justify authorship. All others who contributed to the work who are not authors should be named in the Acknowledgements section.

The list of named authors can only be updated between submission and page proof stage if a letter is sent to the Editor, signed by all original authors, confirming that the alterations are legitimate.

Committee on Publication Ethics (COPE)

As a member of the Committee on Publication Ethics (COPE), adherence to these submission criteria is considered essential for publication in Prenatal Diagnosis ; mandatory fields are included in the online submission process to ensure this. If, at a later stage in the submission process or even after publication, a manuscript or authors are found to have disregarded these criteria, it is the duty of the Editor-in-Chief to report this to COPE. COPE may recommend that action may be taken, including but not exclusive to, informing the authors' professional regulatory body and/or institution of such a dereliction.

The website for COPE may be accessed at:



If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

  • Creative Commons Attribution License OAA
  • Creative Commons Attribution Non-Commercial License OAA
  • Creative Commons Attribution Non-Commercial -NoDerivs OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:


Proofs of accepted articles will be sent to the author for checking. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue.


Free access to the final PDF offprint of your article will be available via Author Services only. Please therefore sign up for Author Services if you would like to access your article PDF offprint and enjoy the many benefits the service offers.

Accepted Articles

'Accepted Articles' have been accepted for publication and undergone full peer review but have not been through the copyediting, typesetting, pagination and proofreading process. Accepted Articles are published online a few days after final acceptance, appear in PDF format only, are given a Digital Object Identifier (DOI), which allows them to be cited and tracked, and are indexed by PubMed. A completed copyright form is required before a manuscript can be processed as an Accepted Article.

Early View

Early View is Wiley's exclusive service presenting individual articles online as soon as they are ready before the release of the compiled print issue. Early View articles are complete, citable and are published in an average time of 6 weeks from acceptance.

Note to NIH grantees

Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMedCentral upon acceptance. This accepted version will be made publicy available 12 months after publication. For further information, click here

The Malcolm Ferguson-Smith Young Investigator Award

In 2007, Prenatal Diagnosis announced The Malcolm Ferguson-Smith Young Investigator Award. In recognition of the Journal’s Founding Editor, an annual prize will be awarded to the best original paper published in a given volume by a young investigator (40 years or younger).