Contents

1. Submission
2. Aims and Scope
3. Manuscript Categories and Requirements
4. Preparing Your Submission
5. Editorial Policies and Ethical Considerations
6. Author Licensing
7. Publication Process After Acceptance
8. Post Publication
9. Editorial Office Contact Details

1. SUBMISSION

Thank you for your interest in Prenatal Diagnosis. Note that submission implies that the content has not been published or submitted for publication elsewhere except as a brief abstract in the proceedings of a scientific meeting or symposium.

Once you have prepared your submission in accordance with the Guidelines, manuscripts should be submitted online at https://mc.manuscriptcentral.com/pd

The submission system will prompt you to use an ORCID iD (a unique author identifier) to help distinguish your work from that of other researchers. Click here to find out more.

Click here for more details on how to use ScholarOne

For help with submissions, please contact: prenataldiagnosis.wiley@gmail.com

We look forward to your submission.

2. AIMS AND SCOPE

Prenatal Diagnosis welcomes submissions in all aspects of prenatal screening and diagnosis with a particular focus on areas in which molecular biology and genetics interface with prenatal care and therapy, encompassing:

• prenatal cytogenetics, including microarrays
• prenatal molecular genetics, including whole exome and whole genome sequencing
• prenatal diagnosis of single gene disorders, including metabolic disorders
• fetal transcriptome, proteome and metabolome studies
• fetal cells and cell-free nucleic acids in maternal blood and other fluids
• preimplantation genetic diagnosis and screening
• fetal and placental development and pathology
• fetal therapy
• prenatal and preconceptional genetic screening
• development and evaluation of laboratory services for prenatal testing
• psychosocial, legal, ethical and economic aspects of prenatal testing
• preconceptual, preimplantation and prenatal genetic counseling

The overriding criteria for publication are scientific merit, originality, and interest to a multidisciplinary audience.

3. MANUSCRIPT CATEGORIES AND REQUIREMENTS

Prenatal Diagnosis publishes a number of different article types including:

• Original Articles
Original articles should contain reports of new research findings or conceptual analyses that make a significant contribution to knowledge. They must include a structured abstract (maximum 200 words), and should not exceed 3,500 words of body text. Original articles must also include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?
• Review Articles
Review Articles will typically be solicited by the Review Editor. Authors who wish to submit an unsolicited review should first contact the Review Editor email: prenataldiagnosis.wiley@gmail.com to determine its suitability for publication in the Journal. All reviews will be peer-reviewed. Review Articles must include an unstructured abstract (maximum 200 words), and should not exceed 3,500 words of body text, and are limited to 150 references. Review articles must also include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?
• Research Letters
Case reports and clinical observations are rarely published and will only be considered if they are of exceptional educational interest, value or novelty. If accepted, they will be published as Research Letters. All Research Letters are peer-reviewed. Research Letters should not exceed 1,500 words, and are limited to 1 table, 1 figure, and 10 references. No abstract or key words are required, and text should be formatted in one continuous section. Research Letters must include bulleted statements (maximum 70 words) in answer to the following questions: what's already known about this topic?; what does this study add?
• Correspondence
Correspondence (letters to the Editor) may be in response to issues arising from recently published articles, or short, free-standing pieces expressing an opinion. Letters are not subject to external peer-review.

4. PREPARING YOUR SUBMISSION

Parts of the Manuscript
Manuscripts must be submitted as a file and should be written in English. The manuscript should be submitted in separate files: title page; main text file; figures; tables.

Covering Letters are encouraged; if you do include a covering letter please consider suggesting an Associate Editor to handle your submission.

Title Page:

The single title page should be presented in the following order:
i. Title
ii. A short running title of less than 70 characters
iii. Manuscript word, table and figure count
iv. The full names of the authors
v. The author's institutional affiliations at which the work was carried out, (footnote for author’s present address if different to where the work was carried out)
vi. Name, address, telephone number and email address of corresponding author
vii. Conflict of interest statement
viii. Funding statement
ix. Bulleted statements (maximum 70 words) in answer to each of the following questions: what's already known about this topic?; what does this study add? (not applicable to Correspondence items.)
x. Abstract

Title
The title should be short and informative, containing major keywords related to the content. The title should not contain abbreviations (see Wiley's best practice SEO tips).

Authorship
For details on eligibility for author listing, please refer to the journal’s Authorship policy outlined in the Editorial Policies and Ethical Considerations section.

Conflict of Interest Statement
Authors will be asked to provide a conflict of interest statement during the submission process. See ‘Conflict of Interest’ section in Editorial Policies and Ethical Considerations for details on what to include in this section. Authors should ensure they liaise with all co-authors to confirm agreement with the final statement.

Funding Statement
See ‘Funding’ section in Editorial Policies and Ethical Considerations for details on what to include in this section.

Abstract
Authors submitting Original Articles should note that structured abstracts (maximum 200 words) are required. The structured abstract should adopt the format: Objective, Method, Results, Conclusion. Abstracts should contain no citation to other published work.
Review Articles require abstracts (maximum 200 words) but they need not be structured.
Research Letters and Correspondence do not require abstracts.

Video Abstracts: A video abstract can be a quick way to make the message of your research accessible to a much larger audience. Wiley and its partner Research Square offer a service of professionally produced video abstracts, available to authors of articles accepted in this journal. You can learn more about it at www.wileyauthors.com/videoabstracts . If you have any questions, please direct them to videoabstracts@wiley.com.

Main Text File and Figures
The main text file should be presented in the following order:
i. Main text
ii. References
iii. Acknowledgements
iv. Figure legends
v. Appendices (if relevant)
Figures, tables and supporting information should be supplied as separate files.

Main text
This should in general, but not necessarily, be divided into sections with the headings: Introduction, Methods, Results, Discussion, Conclusion.
Research Letters and Correspondence should be formatted in one continuous section.

References
References should be in Vancouver format and numbered consecutively in order of appearance. In text citations should cite references in consecutive order using Arabic superscript numerals and should be listed numerically in the reference list at the end of the article.
Format references as below, using standard (Medline) abbreviations for journal titles. If more than four authors, include the first three authors followed by et al.
Sample references follow:

Journal article
1. King VM, Armstrong DM, Apps R, Trott JR. Numerical aspects of pontine, lateral reticular, and inferior olivary projections to two paravermal cortical zones of the cat cerebellum. J Comp Neurol 1998;390:537-551.

Book
2. Voet D, Voet JG. Biochemistry. New York: John Wiley & Sons; 1990. 1223 p. Please note that journal title abbreviations should conform to the practices of Chemical Abstracts.

Internet Document
9. American Cancer Society. Cancer Facts & Figures 2003. http://www.cancer.org/downloads/STT/CAFF2003PWSecured.pdf. Accessed March 3, 2003.

Acknowledgments
Contributions from individuals who do not meet the criteria for authorship should be listed, with permission from the contributor, in an Acknowledgments section. Thanks to anonymous reviewers are not appropriate.

Tables
Tables should be self-contained and complement, but not duplicate, information contained in the text. Tables should not be inserted in the appropriate place in the text but should be included at the end of the paper as an editable file, each on a separate page, with the place to be inserted indicated clearly on the manuscript. They should be referred to in text as Table 1, Table 2.
Legends should be concise but comprehensive – the table, legend and footnotes must be understandable without reference to the text. All abbreviations must be defined in footnotes. Footnote symbols: †, ‡, §, ¶, should be used (in that order) and *, **, *** should be reserved for P-values. Statistical measures such as SD or SEM should be identified in the headings.

Figure Legends
Legends should be concise but comprehensive – the figure and its legend must be understandable without reference to the text. Include definitions of any symbols used and define/explain all abbreviations and units of measurement.

Preparing Figures
Although we encourage authors to send us the highest-quality figures possible, for peer-review purposes we are happy to accept a wide variety of formats, sizes, and resolutions.
Click here for the basic figure requirements for figures submitted with manuscripts for initial peer review, as well as the more detailed post-acceptance figure requirements.
Figures should not be inserted in the appropriate place in the text but should be included at the end of the paper, each on a separate page, and referred to in text as Figure 1, Figure 2.
If you would like to send suggestions for artwork related to your manuscript to be considered to appear on the cover of the journal, please follow these general guidelines

Colour figures
Figures submitted in colour may be reproduced in colour online free of charge. Please note, however, that it is preferable that line figures (e.g. graphs and charts) are supplied in black and white so that they are legible if printed by a reader in black and white. If you wish to have figures printed in colour in hard copies of the journal, a fee will be charged by the Publisher. Colour figures will be printed in the Journal at no cost to the author if colour is necessary to the biomedical understanding (e.g., Doppler, FISH). Non-essential colour reproduction will only be considered on condition that authors contribute to the associated costs. Charges are: £300. (Colour charges will be waived for invited Review Articles.)

Appendices
Appendices will be published after the references. For submission they should be supplied as separate files but referred to in the text.

Supporting Information
Supporting information is information that is not essential to the article but that provides greater depth and background. It is hosted online, and appears without editing or typesetting. It may include tables, figures, videos, datasets, etc. Click here for Wiley’s FAQs on supporting information. Note, if data, scripts or other artefacts used to generate the analyses presented in the paper are available via a publicly available data repository, authors should include a reference to the location of the material within their paper.
Supporting information should be submitted to ScholarOne Manuscripts as 'Supplementary materials for review'.

General Style Points
The following links provide general advice on formatting and style:
• Abbreviations: In general, terms should not be abbreviated unless they are used repeatedly and the abbreviation is helpful to the reader. Initially use the word in full, followed by the abbreviation in parentheses. Thereafter use the abbreviation only.

• Units of measurement: Measurements should be given in SI or SI-derived units. Visit the Bureau International des Poids et Mesures (BIPM) website at http://www.bipm.fr for more information about SI units.

• Numbers: numbers under 10 are spelt out, except for: measurements with a unit (8mmol/l); age (6 weeks old), or lists with other numbers (11 dogs, 9 cats, 4 gerbils).

• Trade Names: Chemical substances should be referred to by the generic name only. Trade names should not be used. Drugs should be referred to by their generic names. If proprietary drugs have been used in the study, refer to these by their generic name, mentioning the proprietary name, and the name and location of the manufacturer, in parentheses.

Wiley Author Resources
Manuscript Preparation Tips
Wiley has a range of resources for authors preparing manuscripts for submission available here. In particular, authors may benefit from referring to Wiley’s best practice tips on Writing for Search Engine Optimization.

Editing, Translation and Formatting Support
Wiley Editing Services can greatly improve the chances of your manuscript being accepted. Offering expert help in English language editing, translation, manuscript formatting and figure preparation, Wiley Editing Services ensures that your manuscript is ready for submission.

5. EDITORIAL POLICIES AND ETHICAL CONSIDERATIONS

Editorial Review and Acceptance
The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are single-blind peer reviewed. Papers will only be sent to review if the Editors-in-Chief determine that the paper meets the appropriate quality and relevance requirements. Wiley's policy on confidentiality of the review process is available here.

Data storage and documentation
Prenatal Diagnosis encourages data sharing wherever possible, unless this is prevented by ethical, privacy or confidentiality matters. Authors publishing in the journal are therefore encouraged to make their data, scripts and other artefacts used to generate the analyses presented in the paper available via a publicly available data repository, however this is not mandatory. If the study includes original data, at least one author must confirm that he or she had full access to all the data in the study, and takes responsibility for the integrity of the data and the accuracy of the data analysis.

MEDLINE
MEDLINE evaluates a journal's ethical policy by checking that journals ask submitting authors to provide three things: a declaration of conflict of interest (CoI), confirmation that informed consent was sought from test subjects, and that animal rights were taken into consideration. The reviewer will then check three things during the review:

1. Policy Exists: is there evidence in the author guidelines that the journal requires that the appropriate ethical requirements are followed.
2. Policy is Adequate: is the policy appropriate for the journal, e.g. a review journal does not need to have a statement on human/animal rights or informed consent.
3. Policy Consistently Followed: is there evidence in all the published articles that authors have declared their conflicts of interest, and that appropriate procedures were followed when the research was conducted. This will be checked in the final published articles.
We recommend that all articles include a statement regarding COI, regardless of whether or not a COI exists – for example “The authors have stated explicitly that there are no conflicts of interest in connection with this article.”

There should be robust journal workflows in place to ensure all three criteria are met. Examples of failures would be: a journal that requires authors to declare that institutional review board (IRB) approval was sought for their research, but this is not communicated to the readers of the final article; journals that do require declarations of informed consent, but don't say so in the author guidelines; or journals that only publish statements when conflicts-of-interest were declared, and assume that all readers know omission means that there aren't any conflicts.

Human Studies and Subjects
For manuscripts reporting medical studies involving human participants, we require a statement identifying the ethics committee that approved the study, and that the study conforms to recognized standards, for example: Declaration of Helsinki; US Federal Policy for the Protection of Human Subjects; or European Medicines Agency Guidelines for Good Clinical Practice.
Images and information from individual participants will only be published where the authors have obtained the individual's free prior informed consent. Authors do not need to provide a copy of the consent form to the publisher, however in signing the author license to publish authors are required to confirm that consent has been obtained. Wiley has a standard patient consent form available for use.

Animal Studies
A statement indicating that the protocol and procedures employed were ethically reviewed and approved, and the name of the body giving approval, must be included in the Methods section of the manuscript. We encourage authors to adhere to animal research reporting standards, for example the ARRIVE reporting guidelines for reporting study design and statistical analysis; experimental procedures; experimental animals and housing and husbandry. Authors should also state whether experiments were performed in accordance with relevant institutional and national guidelines and regulations for the care and use of laboratory animals:
• US authors should cite compliance with the US National Research Council's Guide for the Care and Use of Laboratory Animals, the US Public Health Service's Policy on Humane Care and Use of Laboratory Animals, and Guide for the Care and Use of Laboratory Animals.
• UK authors should conform to UK legislation under the Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039).
• European authors outside the UK should conform to Directive 2010/63/EU.

Clinical Trial Registration
We require that clinical trials are prospectively registered in a publicly accessible database and clinical trial registration numbers should be included in all papers that report their results. Please include the name of the trial register and your clinical trial registration number at the end of your abstract. If your trial is not registered, or was registered retrospectively, please explain the reasons for this.

Research Reporting Guidelines
Accurate and complete reporting enables readers to fully appraise research, replicate it, and use it. We expect authors to adhere to the following guidelines:
CONSORT
SPIRIT
PRISMA
PRISMA-P
STROBE
CARE
COREQ
STARD and TRIPOD
CHEERS
the EQUATOR Network
Future of Research Communications and e-Scholarship (FORCE11)
ARRIVE guidelines
National Research Council's Institute for Laboratory Animal Research guidelines: the Gold Standard Publication Checklist from Hooijmans and colleagues
Minimum Information Guidelines from Diverse Bioscience Communities (MIBBI) website; Biosharing website
REFLECT statement

Species Names
Upon its first use in the title, abstract and text, the common name of a species should be followed by the scientific name (genus, species and authority) in parentheses. For well-known species, however, scientific names may be omitted from article titles. If no common name exists in English, the scientific name should be used only.

Genetic Nomenclature
Sequence variants should be described in the text and tables using both DNA and protein designations whenever appropriate. Sequence variant nomenclature must follow the current HGVS guidelines; see http://varnomen.hgvs.org/, where examples of acceptable nomenclature are provided

Sequence Data
Display of Sequences Prepare sequences as figures, not tables. This will ensure that proper alignment is preserved.

Nucleotide sequence data can be submitted in electronic form to any of the three major collaborative databases: DDBJ, EMBL, or GenBank. It is only necessary to submit to one database as data are exchanged between DDBJ, EMBL, and GenBank on a daily basis. The suggested wording for referring to accession-number information is: ‘These sequence data have been submitted to the DDBJ/EMBL/GenBank databases under accession number U12345’. Addresses are as follows:
• DNA Data Bank of Japan (DDBJ) www.ddbj.nig.ac.jp
• EMBL Nucleotide Archive: ebi.ac.uk/ena
• GenBank www.ncbi.nlm.nih.gov/genbank

Conflict of Interest
The journal requires that all authors disclose any potential sources of conflict of interest. Any interest or relationship, financial or otherwise that might be perceived as influencing an author's objectivity is considered a potential source of conflict of interest. These must be disclosed when directly relevant or directly related to the work that the authors describe in their manuscript. Potential sources of conflict of interest include, but are not limited to, patent or stock ownership, membership of a company board of directors, membership of an advisory board or committee for a company, and consultancy for or receipt of speaker's fees from a company. The existence of a conflict of interest does not preclude publication. If the authors have no conflict of interest to declare, they must also state this at submission. It is the responsibility of the corresponding author to review this policy with all authors and collectively to disclose with the submission ALL pertinent commercial and other relationships.

Funding
Authors should list all funding sources in the Funding Statement. Authors are responsible for the accuracy of their funder designation. If in doubt, please check the Open Funder Registry for the correct nomenclature: http://www.crossref.org/fundingdata/registry.html

Authorship
The list of authors should accurately illustrate who contributed to the work and how. All those listed as authors should qualify for authorship according to the following criteria:
1. Have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data;
2. Been involved in drafting the manuscript or revising it critically for important intellectual content;
3. Given final approval of the version to be published. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content; and
4. Agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Contributions from anyone who does not meet the criteria for authorship should be listed, with permission from the contributor, in an Acknowledgments section (for example, to recognize contributions from people who provided technical help, collation of data, writing assistance, acquisition of funding, or a department chairperson who provided general support). Prior to submitting the article all authors should agree on the order in which their names will be listed in the manuscript.

Additional authorship options
Joint first or senior authorship: In the case of joint first authorship a footnote should be added to the author listing, e.g. ‘X and Y should be considered joint first author’ or ‘X and Y should be considered joint senior author.’

ORCID
As part of our commitment to supporting authors at every step of the publishing process, Prenatal Diagnosis requires the submitting author (only) to provide an ORCID iD when submitting a manuscript. This takes around 2 minutes to complete. Find more information.

Publication Ethics
This journal is a member of the Committee on Publication Ethics (COPE). Note this journal uses iThenticate’s CrossCheck software to detect instances of overlapping and similar text in submitted manuscripts. Read our Top 10 Publishing Ethics Tips for Authors here. Wiley’s Publication Ethics Guidelines can be found at https://authorservices.wiley.com/ethics-guidelines/index.html

Clinical Case Reports
We work together with Wiley’s open access journals, Molecular Genetics and Genomic Medicine and Clinical Case Reports to enable rapid publication of good quality papers and case reports respectively, that we are unable to accept for publication in our journal. Authors rejected by our journal will be offered the option of having their paper or case report, along with any related peer reviews, automatically transferred for consideration by the Molecular Genetics and Genomic Medicine or Clinical Case Reports editorial team. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place.
Clinical Case Reports will consider case reports from every clinical discipline and may include clinical images or clinical videos. Clinical Case Reports is an open access journal, and article publication fees apply. For more information please see their website. For more information on Molecular Genetics and Genomic Medicine please go to their website. p>

6. AUTHOR LICENSING

If your paper is accepted, the author identified as the formal corresponding author will receive an email prompting them to log in to Author Services, where via the Wiley Author Licensing Service (WALS) they will be required to complete a copyright license agreement on behalf of all authors of the paper.
Authors may choose to publish under the terms of the journal’s standard copyright agreement, or OnlineOpen under the terms of a Creative Commons License.
General information regarding licensing and copyright is available here. To review the Creative Commons License options offered under OnlineOpen, please click here. (Note that certain funders mandate that a particular type of CC license has to be used; to check this please click here.)

Self-Archiving definitions and policies. Note that the journal’s standard copyright agreement allows for self-archiving of different versions of the article under specific conditions. Please click here for more detailed information about self-archiving definitions and policies.

Open Access fees: If you choose to publish using OnlineOpen you will be charged a fee. A list of Article Publication Charges for Wiley journals is available here.

Funder Open Access: Please click here for more information on Wiley’s compliance with specific Funder Open Access Policies.

7. PUBLICATION PROCESS AFTER ACCEPTANCE

Accepted article received in production
When your accepted article is received by Wiley’s production team, you (corresponding author) will receive an email asking you to login or register with Author Services. You will be asked to sign a publication license at this point.

Accepted Articles
The journal offers Wiley’s Accepted Articles service for all manuscripts. This service ensures that accepted ‘in press’ manuscripts are published online very soon after acceptance, prior to copy-editing or typesetting. Accepted Articles are published online a few days after final acceptance, appear in PDF format only, are given a Digital Object Identifier (DOI), which allows them to be cited and tracked, and are indexed by PubMed. After publication of the final version article (the article of record), the DOI remains valid and can continue to be used to cite and access the article.
Accepted Articles will be indexed by PubMed; submitting authors should therefore carefully check the names and affiliations of all authors provided in the cover page of the manuscript so it is correct for indexing. Subsequently the final copyedited and proofed articles will appear in an issue on Wiley Online Library; the link to the article in PubMed will automatically be updated.

Proofs
Once your paper is typeset you will receive an email notification of the URL from where to download a PDF typeset page proof, associated forms and full instructions on how to correct and return the file.
Please note that you are responsible for all statements made in your work, including changes made during the editorial process and thus you must check your proofs carefully. Note that proofs should be returned 48 hours from receipt of first proof.

Publication Charges
Once your paper is typeset you will receive an email notification of the URL from where to download a PDF typeset page proof, associated forms and full instructions on how to correct and return the file.
Please note that you are responsible for all statements made in your work, including changes made during the editorial process and thus you must check your proofs carefully. Note that proofs should be returned 48 hours from receipt of first proof.

Early View
The journal offers rapid publication via Wiley’s Early View service. Early View (Online Version of Record) articles are published on Wiley Online Library before inclusion in an issue. Note there may be a delay after corrections are received before your article appears online, as Editors also need to review proofs. Once your article is published on Early View no further changes to your article are possible. Your Early View article is fully citable and carries an online publication date and DOI for citations.

8. POST PUBLICATION

Access and sharing
When your article is published online:
• You receive an email alert (if requested).
• You can share a link to your published article through social media.
• As the author, you will have free access to your paper (after accepting the Terms & Conditions of use, you can view your article).
• The corresponding author and co-authors can nominate up to ten colleagues to receive a publication alert and free online access to your article. You can now order print copies of your article (instructions are sent at proofing stage or use the below contact details).
Email offprint@cosprinters.com
Now is the time to start promoting your article. Find out how to do that here.

Measuring the Impact of your Work
Wiley also helps you measure the impact of your research through our specialist partnerships with Kudos and Altmetric.

9. EDITORIAL OFFICE CONTACT DETAILS

For queries about submissions, please contact prenataldiagnosis.wiley@gmail.com

Author Guidelines Updated 31st March 2017